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| 카탈로그 번호 | HX213014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ARPP19 (Ser2-Leu77). | ||||||||
| 타겟 | cAMP-regulated phosphoprotein 19, ARPP19, ARPP-19 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P56211 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | cAMP-regulated phosphoprotein 19 (ARPP19) is a ~12 kDa protein. Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Inhibition of PP2A is enhanced when ARPP19 is phosphorylated. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression. 1. Padi, SKR. et al. (2024) Nature 625, 195-203. PMID: 38123684 2. Gharbi-Ayachi, A. et al. (2010) Science (New York, N.Y.) 330, 1673-7. PMID: 21164014 | ||||||||
| 참고사항 | For research use only. |
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