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| 카탈로그 번호 | HY187014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human ASL Polyclonal Antibody (HY187014) is a rabbit polyclonal antibody detecting ASL in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human ASL (Met1-Ala464). | ||||||||
| 타겟 | ASAL, Arginosuccinase, Argininosuccinate lyase, ASL | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P04424 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Argininosuccinate lyase (ASL) is a ~51 kDa protein. Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway. 1. Sampaleanu, LM. et al. (2001) Biochemistry 40, 15570-80. PMID: 11747432 2. Yu, B. et al. (2001) Biochemistry 40, 15581-90. PMID: 11747433 3. Erez, A. et al. (2011) Nature medicine 17, 1619-26. PMID: 22081021 4. Walker, DC. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9625-9. PMID: 2263616 5. Walker, DC. et al. (1997) The Journal of biological chemistry 272, 6777-83. PMID: 9045711 | ||||||||
| 참고사항 | For research use only. |
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