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| 카탈로그 번호 | HC491043 | ||||||
|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||
| 응용 분야 | ELISA, WB | ||||||
| 숙주 종 | Mouse | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | IgG2a | ||||||
| 클론 ID | 3C10 | ||||||
| 타겟 | BAX, BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4 | ||||||
| 내독소 수준 | < 10 EU/mg | ||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | Q07812 | ||||||
| RRID | Anti-Human BAX Antibody (3C10) (abinScience Cat# HC491043, RRID:AB_3729489) |
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| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 배경 | Apoptosis regulator BAX is a ~21 kDa protein. Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. 1. Schmitt, E. et al. (2000) Biochemical and biophysical research communications 270, 868-79. PMID: 10772918 2. Tan, KO. et al. (2001) The Journal of biological chemistry 276, 2802-7. PMID: 11060313 3. Zhang, H. et al. (2005) Nature cell biology 7, 909-15. PMID: 16113678 4. Tan, KO. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 14623-8. PMID: 16199525 5. Gavathiotis, E. et al. (2008) Nature 455, 1076-81. PMID: 18948948 6. Czabotar, PE. et al. (2011) The Journal of biological chemistry 286, 7123-31. PMID: 21199865 7. Edlich, F. et al. (2011) Cell 145, 104-16. PMID: 21458670 8. Wei, B. et al. (2015) Journal of virology 89, 3804-18. PMID: 25609812 9. Choi, HS. et al. (2022) International journal of molecular sciences 23. PMID: 36361894 10. Oltvai, ZN. et al. (1993) Cell 74, 609-19. PMID: 8358790 | ||||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human BAX Antibody (3C10)
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