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| 카탈로그 번호 | HF603014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human BCAS2 (Met1-Phe225). | ||||||||
| 타겟 | DNA amplified in mammary carcinoma 1 protein, BCAS2, DAM1, Breast carcinoma-amplified sequence 2, Pre-mRNA-splicing factor SPF27, Spliceosome-associated protein SPF 27 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | O75934 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Pre-mRNA-splicing factor SPF27 (BCAS2) is a ~26 kDa protein. Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). 1. Bertram, K. et al. (2017) Nature 542, 318-323. PMID: 28076346 2. Zhang, X. et al. (2017) Cell 169, 918-929.e14. PMID: 28502770 3. Zhan, X. et al. (2018) Science (New York, N.Y.) 359, 537-545. PMID: 29301961 4. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106 5. Fica, SM. et al. (2019) Science (New York, N.Y.) 363, 710-714. PMID: 30705154 | ||||||||
| 참고사항 | For research use only. |
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