中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HP393014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human BIRC7 (Ser86-Ser176). | ||||||||
| 타겟 | BIRC7, p30-Livin, Melanoma inhibitor of apoptosis protein, LIVIN, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, Truncated livin, RNF50, KIAP, Livin, RING-type E3 ubiquitin transferase BIRC7, RING finger protein 50, tLivin, MLIAP, ML-IAP | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q96CA5 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Baculoviral IAP repeat-containing protein 7 (BIRC7) is a ~32 kDa protein. Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. 1. Kasof, GM. et al. (2001) The Journal of biological chemistry 276, 3238-46. PMID: 11024045 2. Vucic, D. et al. (2000) Current biology : CB 10, 1359-66. PMID: 11084335 3. Lin, JH. et al. (2000) Biochemical and biophysical research communications 279, 820-31. PMID: 11162435 4. Ma, L. et al. (2006) Cell death and differentiation 13, 2079-88. PMID: 16729033 5. Nachmias, B. et al. (2007) Apoptosis : an international journal on programmed cell death 12, 1129-42. PMID: 17294084 | ||||||||
| 참고사항 | For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
