中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HB192014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human BRD2 (Arg74-Gln182). | ||||||||
| 타겟 | Really interesting new gene 3 protein, KIAA9001, O27.1.1, BRD2, RING3, Bromodomain-containing protein 2 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P25440 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Bromodomain-containing protein 2 (BRD2) is a ~88 kDa protein. Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation. Also recognizes and binds acetylated non-histone proteins, such as STAT3. Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin. 1. Nakamura, Y. et al. (2007) The Journal of biological chemistry 282, 4193-201. PMID: 17148447 2. Huang, H. et al. (2007) BMC structural biology 7, 57. PMID: 17848202 3. LeRoy, G. et al. (2008) Molecular cell 30, 51-60. PMID: 18406326 4. Umehara, T. et al. (2010) The Journal of biological chemistry 285, 7610-8. PMID: 20048151 5. Umehara, T. et al. (2010) FEBS letters 584, 3901-8. PMID: 20709061 6. Filippakopoulos, P. et al. (2010) Nature 468, 1067-73. PMID: 20871596 7. Cheung, KL. et al. (2017) Molecular cell 65, 1068-1080.e5. PMID: 28262505 8. Xie, L. et al. (2022) Nature genetics 54, 481-491. PMID: 35410381 | ||||||||
| 참고사항 | For research use only. |
Lane 1: C2C12 cell lysate
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
