Anti-Human BRD2 IP Recombinant Antibody (SAA0190) (HB192013)

Name: Anti-Human BRD2 IP Recombinant Antibody (SAA0190)
Brand: abinScience
SKU: HB192013
Price: 126 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HB192013

Species reactivity

Human

Applications

ELISA, IF, IP, IP-MS

Host species

Mouse

Isotype

IgG

Clone ID

SAA0190

Clonality

Monoclonal

Target

Really interesting new gene 3 protein, KIAA9001, O27.1.1, BRD2, RING3, Bromodomain-containing protein 2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P25440

RRID

Anti-Human BRD2 IP Antibody (SAA0190) (abinScience Cat# HB192013, RRID:AB_3729724)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Bromodomain-containing protein 2 (BRD2) is a ~88 kDa protein. Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation. Also recognizes and binds acetylated non-histone proteins, such as STAT3. Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin.

1. Nakamura, Y. et al. (2007) The Journal of biological chemistry 282, 4193-201. PMID: 17148447

2. Huang, H. et al. (2007) BMC structural biology 7, 57. PMID: 17848202

3. LeRoy, G. et al. (2008) Molecular cell 30, 51-60. PMID: 18406326

4. Umehara, T. et al. (2010) The Journal of biological chemistry 285, 7610-8. PMID: 20048151

5. Umehara, T. et al. (2010) FEBS letters 584, 3901-8. PMID: 20709061

6. Filippakopoulos, P. et al. (2010) Nature 468, 1067-73. PMID: 20871596

7. Cheung, KL. et al. (2017) Molecular cell 65, 1068-1080.e5. PMID: 28262505

8. Xie, L. et al. (2022) Nature genetics 54, 481-491. PMID: 35410381

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human BRD2 IP Antibody (SAA0190)

References

Datasheet

Anti-Human BRD2 IP Recombinant Antibody (SAA0190).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human BRD2 IP Recombinant Antibody (SAA0190) (HB192013)

Overview

Images

References

Datasheet

SDS

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