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| 카탈로그 번호 | HB973013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1757 | ||||
| 타겟 | CT-R, CALCR, Calcitonin receptor | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P30988 | ||||
| RRID | Anti-Human CALCR/Calcitonin receptor/CT-R Antibody (SAA1757) (abinScience Cat# HB973013, RRID:AB_3727518) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Calcitonin receptor (CALCR/CT-R) is a ~55 kDa protein. G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. 1. Cao, J. et al. (2022) Science (New York, N.Y.) 375, eabm9609. PMID: 35324283 2. Cao, J. et al. (2024) Biochemistry 63, 1089-1096. PMID: 38603770 3. Moore, EE. et al. (1995) Molecular endocrinology (Baltimore, Md.) 9, 959-68. PMID: 7476993 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CALCR/Calcitonin receptor/CT-R Antibody (SAA1757)
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