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| 카탈로그 번호 | HC541013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1742 | ||||
| 타겟 | GPI-anchored protein p137, Cytoplasmic activation- and proliferation-associated protein 1, p137GPI, RNG105, M11S1, Caprin-1, Cell cycle-associated protein 1, RNA granule protein 105, CAPRIN1, GPIP137, GPI-anchored membrane protein 1, GPI-p137, GPIAP1, Membrane component chromosome 11 surface marker 1 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | Q14444 | ||||
| RRID | Anti-Human CAPRIN1 Antibody (SAA1742) (abinScience Cat# HC541013, RRID:AB_3727503) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Caprin-1 (CAPRIN1) is a ~78 kDa protein. mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Plays an essential role in cytoplasmic stress granule formation. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. 1. Solomon, S. et al. (2007) Molecular and cellular biology 27, 2324-42. PMID: 17210633 2. Kim, TH. et al. (2019) Science (New York, N.Y.) 365, 825-829. PMID: 31439799 3. Pavinato, L. et al. (2023) Brain : a journal of neurology 146, 534-548. PMID: 35979925 4. Jia, X. et al. (2022) Science advances 8, eabo7112. PMID: 35977029 5. Sanders, DW. et al. (2020) Cell 181, 306-324.e28. PMID: 32302570 6. Yang, P. et al. (2020) Cell 181, 325-345.e28. PMID: 32302571 7. Guillén-Boixet, J. et al. (2020) Cell 181, 346-361.e17. PMID: 32302572 8. Kim, TH. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34074792 9. Toyama, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2210492119. PMID: 36040869 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CAPRIN1 Antibody (SAA1742)
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