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| 카탈로그 번호 | HY332107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | Mab1 |
| 타겟 | LAMP1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP-1, Lysosome-associated membrane glycoprotein 1 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P11279 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. 1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818 2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921 3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890 4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195 5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349 |
| 참고사항 | For research use only. |
Detects CD107a/LAMP1 in indirect ELISAs.
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
