Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), PerCP (HY332147)

Name: Anti-Human CD107a/LAMP1 Recombinant Antibody (Mab1), PerCP
Brand: abinScience
SKU: HY332147
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HY332147
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	Mab1
Conjugation	PerCP
Clonality	Monoclonal
Target	LAMP1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, CD107a, LAMP-1, Lysosome-associated membrane glycoprotein 1
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PerCP
Accession	P11279
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. 1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818 2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921 3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890 4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195 5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.