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| 카탈로그 번호 | HW498107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | SAA1388 |
| 타겟 | Cytokine receptor common subunit beta, IL3RB, IL5RB, CDw131, CD131, CSF2RB, GM-CSF/IL-3/IL-5 receptor common beta subunit |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P32927 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Cytokine receptor common subunit beta (CD131/CSF2RB) is a ~97 kDa protein. Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. 1. Tavernier, J. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 7041-5. PMID: 1495999 2. Ogata, N. et al. (1998) Blood 91, 2264-71. PMID: 9516124 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human CD131/CSF2RB Antibody (SAA1388)
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