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Anti-Human CD131/CSF2RB Recombinant Antibody (SAA1389) (HW498207)

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Anti-Human CD131/CSF2RB Recombinant Antibody (SAA1389)

Anti-Human CD131/CSF2RB Recombinant Antibody (SAA1389)

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Overview

Catalog No.	HW498207
Description	Anti-Human CD131/CSF2RB Antibody (SAA1389) [SAA1389] (HW498207) is a mouse monoclonal antibody detecting CSF2RB in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	SAA1389
Clonality	Monoclonal
Target	Cytokine receptor common subunit beta, IL3RB, IL5RB, CDw131, CD131, CSF2RB, GM-CSF/IL-3/IL-5 receptor common beta subunit
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P32927
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Cytokine receptor common subunit beta (CD131/CSF2RB) is a ~97 kDa protein. Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. 1. Tavernier, J. et al. (1992) Proceedings of the National Academy of Sciences of the United States of America 89, 7041-5. PMID: 1495999 2. Ogata, N. et al. (1998) Blood 91, 2264-71. PMID: 9516124
Note	For research use only.

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Bioactivity

Detects CD131/CSF2RB in indirect ELISAs.

References

Datasheet

Anti-Human CD131/CSF2RB Recombinant Antibody (SAA1389).pdf

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Anti-Human CD131/CSF2RB Recombinant Antibody (SAA1389)