Anti-Human TLR4 Monoclonal Antibody (1A057) (HT205025)

Name: Anti-Human TLR4 Monoclonal Antibody (1A057)
Brand: abinScience
SKU: HT205025
Price: 106 USD
Availability: InStock

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개요

카탈로그 번호	HT205025
설명	Anti-Human CD284/TLR4 Monoclonal Antibody (1A057) [1A057] (HT205025) is a mouse monoclonal antibody detecting CD284 in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, IHC, WB
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG3
클론 ID	1A057
면역원	Mammalian cells - derived recombinant Human CD284 / TLR4 (Met1-Lys631).
타겟	Toll-like receptor 4, TLR4, CD284, hToll,
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Toll-like receptor 4 (CD284/TLR4) is a ~95 kDa protein. Transmembrane receptor that functions as a pattern recognition receptor recognizing pathogen- and damage-associated molecular patterns (PAMPs and DAMPs) to induce innate immune responses via downstream signaling pathways. At the plasma membrane, cooperates with LY96 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Mechanistically, acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Alternatively, CD14-mediated TLR4 internalization via endocytosis is associated with the initiation of a MYD88-independent signaling via the TICAM1-TBK1-IRF3 axis leading to type I interferon production. 1. Arbour, NC. et al. (2000) Nature genetics 25, 187-91. PMID: 10835634 2. Bulut, Y. et al. (2005) The Journal of biological chemistry 280, 20961-7. PMID: 15809303 3. Jung, SB. et al. (2006) Infection and immunity 74, 2686-96. PMID: 16622205 4. Georgel, P. et al. (2007) Virology 362, 304-13. PMID: 17292937 5. Kim, F. et al. (2007) Circulation research 100, 1589-96. PMID: 17478729 6. Stewart, CR. et al. (2010) Nature immunology 11, 155-61. PMID: 20037584 7. Schmidt, M. et al. (2010) Nature immunology 11, 814-9. PMID: 20711192 8. Estruch, M. et al. (2013) Atherosclerosis 229, 356-62. PMID: 23880187 9. Tatematsu, M. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3865-76. PMID: 27022195 10. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465
참고사항	For research use only.