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| 카탈로그 번호 | HB625107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | E11 |
| 타겟 | C3BR, Complement receptor type 1, CR1, CD35, C3b/C4b receptor |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P17927 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. 1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069 2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794 3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757 4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728 |
| 참고사항 | For research use only. |
SEC-HPLC detection for Anti-Human CD35/CR1 Antibody (E11).
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