Anti-Human CD35/CR1 Recombinant Antibody (E11), PE (HB625127)

Name: Anti-Human CD35/CR1 Recombinant Antibody (E11), PE
Brand: abinScience
SKU: HB625127
Price: 256 USD
Availability: InStock

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Overview

Catalog No.	HB625127
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	E11
Conjugation	PE
Clonality	Monoclonal
Target	C3BR, Complement receptor type 1, CR1, CD35, C3b/C4b receptor
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), PE
Accession	P17927
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Complement receptor type 1 (CD35/CR1) is a ~223 kDa protein. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Also acts in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. 1. Schifferli, JA. et al. (1988) Journal of immunology (Baltimore, Md. : 1950) 140, 899-904. PMID: 2963069 2. Klickstein, LB. et al. (1988) The Journal of experimental medicine 168, 1699-717. PMID: 2972794 3. Krych, M. et al. (1994) The Journal of biological chemistry 269, 13273-8. PMID: 8175757 4. Török, K. et al. (2015) Immunology letters 164, 117-24. PMID: 25742728
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD35/CR1 Recombinant Antibody (E11), PE.pdf

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Anti-Human CD35/CR1 Recombinant Antibody (E11), PE (HB625127)

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