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| 카탈로그 번호 | HV585137 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | NT-7 |
| 접합 | APC |
| 타겟 | CD352, NTB-A, NK-T-B-antigen, KALI, SLAMF6, Activating NK receptor, SLAM family member 6 |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC |
| 등록번호 | Q96DU3 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | SLAM family member 6 (CD352/SLAMF6) is a ~37 kDa protein. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. Positive signaling in NK cells implicates phosphorylation of VAV1. 1. Bottino, C. et al. (2001) The Journal of experimental medicine 194, 235-46. PMID: 11489943 2. Eissmann, P. et al. (2006) Journal of immunology (Baltimore, Md. : 1950) 177, 3170-7. PMID: 16920955 3. Chatterjee, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 1206-12. PMID: 22184727 4. Chatterjee, M. et al. (2012) The Journal of biological chemistry 287, 38168-77. PMID: 22989874 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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