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| 카탈로그 번호 | HV778117 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2b, kappa |
| 클론 ID | 9B9 |
| 접합 | FITC |
| 타겟 | CD368, CLECSF8, C-type lectin domain family 4 member D, C-type lectin superfamily member 8, MCL, C-type lectin-like receptor 6, CLEC4D, CLEC-6 |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Mouse IgG2b, kappa Recombinant Isotype Control Antibody (MPC-11), FITC |
| 등록번호 | Q8WXI8 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | C-type lectin domain family 4 member D (CD368/CLEC4D) is a ~24 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. 1. Miyake, Y. et al. (2013) Immunity 38, 1050-62. PMID: 23602766 2. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656 3. Arce, I. et al. (2004) European journal of immunology 34, 210-20. PMID: 14971047 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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