Anti-Human MICL/CLEC12A Recombinant Antibody (SAA0102) (HV493107)

Name: Anti-Human MICL/CLEC12A Recombinant Antibody (SAA0102)
Brand: abinScience
SKU: HV493107
Price: 191 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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개요
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참고 문헌
데이터시트
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개요

카탈로그 번호	HV493107
종 반응성	Human
응용 분야	FCM
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG2a, kappa
클론 ID	SAA0102
타겟	CLEC12A, DCAL2, Dendritic cell-associated lectin 2, CLL-1, Myeloid inhibitory C-type lectin-like receptor, C-type lectin domain family 12 member A, CLL1, DCAL-2, C-type lectin-like molecule 1, MICL, CD371
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q5QGZ9
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
배경	C-type lectin domain family 12 member A (CD371/CLEC12A) is a ~30 kDa protein. Myeloid inhibitory C-type lectin receptor that acts as a negative regulator of myeloid cell activation. Myeloid cell inhibition is required to limit proinflammatory pathways and protect against excessive inflammation. Specifically recognizes and binds various structures, such as neutrophil extracellular traps (NETs) or monosodium urate crystals. Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid. Ligand-binding induces phosphorylation of its ITIM motif, followed by recruitment of tyrosine-protein phosphatases PTPN6 and PTPN11, which counteract tyrosine-protein kinase SYK, thereby preventing myeloid cell activation. 1. Marshall, AS. et al. (2004) The Journal of biological chemistry 279, 14792-802. PMID: 14739280 2. Han, Y. et al. (2004) Blood 104, 2858-66. PMID: 15238421 3. Chen, CH. et al. (2006) Blood 107, 1459-67. PMID: 16239426 4. Paré, G. et al. (2021) Frontiers in immunology 12, 650808. PMID: 34234773 5. Tang, H. et al. (2024) The Journal of biological chemistry 300, 105765. PMID: 38367667 6. Mori, S. et al. (2024) International immunology 36, 279-290. PMID: 38386511 7. Malamud, M. et al. (2024) Nature 633, 442-450. PMID: 39143217
참고사항	For research use only.