Anti-Human CD3G Monoclonal Antibody (1A636) (HB395015)

Name: Anti-Human CD3G Monoclonal Antibody (1A636)
Brand: abinScience
SKU: HB395015
Price: 106 USD
Availability: InStock

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개요

카탈로그 번호	HB395015
설명	Anti-Human CD3G Monoclonal Antibody (1A636) [1A636] (HB395015) is a mouse monoclonal antibody detecting CD3g in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, IHC, WB
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG
클론 ID	1A636
면역원	Mammalian cells - derived recombinant human CD3G (Met1-Ser116).
타겟	T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g, CD3G
정제	Protein A/G purified from cell culture supernatant.
등록번호	P09693
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	T-cell surface glycoprotein CD3 gamma chain (CD3G) is a ~20 kDa protein. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. 1. Barber, EK. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 3277-81. PMID: 2470098 2. Dietrich, J. et al. (1994) The EMBO journal 13, 2156-66. PMID: 8187769
참고사항	For research use only.