Anti-Human CD3G Monoclonal Antibody (1A637) (HB395025)

Name: Anti-Human CD3G Monoclonal Antibody (1A637)
Brand: abinScience
SKU: HB395025
Price: 106 USD
Availability: InStock

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Overview

Catalog No.	HB395025
Description	Anti-Human CD3G Monoclonal Antibody (1A637) [1A637] (HB395025) is a mouse monoclonal antibody detecting CD3g in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A637
Clonality	Monoclonal
Immunogen	Mammalian cells - derived recombinant human CD3G (Met1-Ser116).
Target	T-cell surface glycoprotein CD3 gamma chain, T-cell receptor T3 gamma chain, CD3g, CD3G
Purification	Protein A/G purified from cell culture supernatant.
Accession	P09693
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	T-cell surface glycoprotein CD3 gamma chain (CD3G) is a ~20 kDa protein. Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. 1. Barber, EK. et al. (1989) Proceedings of the National Academy of Sciences of the United States of America 86, 3277-81. PMID: 2470098 2. Dietrich, J. et al. (1994) The EMBO journal 13, 2156-66. PMID: 8187769
Note	For research use only.