Anti-Human CD48/SLAMF2 Recombinant Antibody (156-4H9), APC (HY573237)

Name: Anti-Human CD48/SLAMF2 Recombinant Antibody (156-4H9), APC
Brand: abinScience
SKU: HY573237
Price: 256 USD
Availability: InStock

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개요

카탈로그 번호	HY573237
종 반응성	Human
응용 분야	FCM
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	156-4H9
접합	APC
타겟	Signaling lymphocytic activation molecule 2, TCT.1, CD48 antigen, B-lymphocyte activation marker BLAST-1, BCM1, CD48, BLAST1, Leukocyte antigen MEM-102, SLAMF2, BCM1 surface antigen, SLAM family member 2
내독소 수준	Please contact with the lab for this information.
관련 제품	Mouse IgG1, kappa Recombinant Isotype Control Antibody (MOPC-21), APC
등록번호	P09326
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	CD48 antigen is a ~27 kDa protein. Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. 1. Hawash, IY. et al. (2002) Biochimica et biophysica acta 1589, 140-50. PMID: 12007789 2. Muhammad, A. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 7672-80. PMID: 19494291 3. Claus, M. et al. (2016) Open biology 6. PMID: 27249817 4. Brown, MH. et al. (1998) The Journal of experimental medicine 188, 2083-90. PMID: 9841922
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.