Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC (HY464137)

Name: Anti-Human CD49e/ITGA5 Recombinant Antibody (SAA0021), APC
Brand: abinScience
SKU: HY464137
Price: 256 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

50T
100T

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HY464137
종 반응성	Human
응용 분야	FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4
클론 ID	SAA0021
접합	APC
타겟	CD49 antigen-like family member E, Integrin alpha-F, ITGA5, VLA-5, Fibronectin receptor subunit alpha, CD49e, Integrin alpha-5, FNRA
내독소 수준	Please contact with the lab for this information.
관련 제품	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), APC
등록번호	P08648
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Integrin alpha-5 (CD49e/ITGA5) is a ~114 kDa protein. Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1. 1. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 2. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877 3. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887 4. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 5. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943 6. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430 7. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

이미지

Flow CytoMetry

Flow-cytometry using APC anti-human CD49e antibody. HUVEC cells were stained with an irrelevant antibody (Blue Histogram) or an APC anti-human CD49e monoclonal antibody (Catalog: HY464137, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

참고 문헌

데이터시트