Anti-Human CDCA7 Polyclonal Antibody (HP761014)

Name: Anti-Human CDCA7 Polyclonal Antibody
Brand: abinScience
SKU: HP761014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HP761014

설명

Anti-Human CDCA7 Polyclonal Antibody (HP761014) is a rabbit polyclonal antibody detecting CDCA7 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human CDCA7 (Thr246-Ala371).

타겟

CDCA7, JPO1, Cell division cycle-associated protein 7, Protein JPO1

정제

Purified by antigen affinity column.

등록번호

Q9BWT1

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Cell division cycle-associated protein 7 (CDCA7) is a ~42 kDa protein. Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns. May play a role as transcriptional regulator.

1. Prescott, JE. et al. (2001) The Journal of biological chemistry 276, 48276-84. PMID: 11598121

2. Osthus, RC. et al. (2005) Cancer research 65, 5620-7. PMID: 15994934

3. Gill, RM. et al. (2013) Molecular and cellular biology 33, 498-513. PMID: 23166294

4. Unoki, M. et al. (2019) The Journal of clinical investigation 129, 78-92. PMID: 30307408

5. Wassing, IE. et al. (2024) Science advances 10, eadp5753. PMID: 39178260

6. Goto, Y. et al. (2006) Biochimica et biophysica acta 1759, 60-8. PMID: 16580749

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human CDCA7 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human CDCA7 Polyclonal Antibody (HP761014)

개요

이미지

참고 문헌

데이터시트

SDS