Anti-Human CFTR Monoclonal Antibody (1A510) (HY313035)

Name: Anti-Human CFTR Monoclonal Antibody (1A510)
Brand: abinScience
SKU: HY313035
Price: 106 USD
Availability: InStock

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개요

카탈로그 번호	HY313035
설명	Anti-Human CFTR Monoclonal Antibody (1A510) [1A510] (HY313035) is a mouse monoclonal antibody detecting CFTR in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
종 반응성	Human
응용 분야	ELISA, IHC, WB
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG
클론 ID	1A510
면역원	E. coli - derived recombinant human CFTR (Ile1203-Ser1426).
타겟	Cystic fibrosis transmembrane conductance regulator, CFTR, ATP-binding cassette sub-family C member 7, Channel conductance-controlling ATPase, EC:5.6.1.6, cAMP-dependent chloride channel, CFTR
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P13569
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Cystic fibrosis transmembrane conductance regulator (CFTR) is a ~168 kDa protein. Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. In vitro, mediates ATP-dependent glutathione flux. 1. Shah, VS. et al. (2016) Science (New York, N.Y.) 351, 503-7. PMID: 26823428 2. Ostedgaard, LS. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5657-62. PMID: 10792060 3. Ramjeesingh, M. et al. (2001) Biochemistry 40, 10700-6. PMID: 11524016 4. Cheng, J. et al. (2002) The Journal of biological chemistry 277, 3520-9. PMID: 11707463 5. Hallows, KR. et al. (2003) American journal of physiology. Cell physiology 284, C1297-308. PMID: 12519745 6. Silvis, MR. et al. (2003) The Journal of biological chemistry 278, 11554-60. PMID: 12529365 7. Chappe, V. et al. (2003) The Journal of physiology 548, 39-52. PMID: 12588899 8. Kogan, I. et al. (2003) The EMBO journal 22, 1981-9. PMID: 12727866 9. Shcheynikov, N. et al. (2004) The Journal of biological chemistry 279, 21857-65. PMID: 15010471 10. Mense, M. et al. (2006) The EMBO journal 25, 4728-39. PMID: 17036051
참고사항	For research use only.

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Anti-Human CFTR Monoclonal Antibody (1A510).pdf

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Anti-Human CFTR Monoclonal Antibody (1A510) (HY313035)

개요

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데이터시트

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