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| 카탈로그 번호 | HW810013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1641 | ||||
| 타겟 | TSP5, Thrombospondin-5, COMP, Cartilage oligomeric matrix protein | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P49747 | ||||
| RRID | Anti-Human COMP Antibody (SAA1641) (abinScience Cat# HW810013, RRID:AB_3727402) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Cartilage oligomeric matrix protein (COMP) is a ~82 kDa protein. Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). 1. Chen, FH. et al. (2005) The Journal of biological chemistry 280, 32655-61. PMID: 16051604 2. Koelling, S. et al. (2006) Arthritis research & therapy 8, R56. PMID: 16542502 3. Gagarina, V. et al. (2008) The Journal of biological chemistry 283, 648-659. PMID: 17993464 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human COMP Antibody (SAA1641)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
