Anti-Human DHX16 Polyclonal Antibody (HT408014)

Name: Anti-Human DHX16 Polyclonal Antibody
Brand: abinScience
SKU: HT408014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HT408014

설명

Anti-Human DHX16 Polyclonal Antibody (HT408014) is a rabbit polyclonal antibody detecting DHX16 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human DHX16 (Glu364-Glu746).

타겟

Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16, 3.6.4.13, ATP-dependent RNA helicase #3, DEAH-box protein 16, DHX16, DBP2, DDX16, KIAA0577, PRP2

정제

Purified by antigen affinity column.

등록번호

O60231

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 is a ~119 kDa protein. Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses.

1. Gencheva, M. et al. (2010) The Biochemical journal 429, 25-32. PMID: 20423332

2. Gencheva, M. et al. (2010) The Journal of biological chemistry 285, 35624-32. PMID: 20841358

3. Zang, S. et al. (2014) Bioscience reports 34, e00163. PMID: 25296192

4. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106

5. Hage, A. et al. (2022) Cell reports 38, 110434. PMID: 35263596

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human DHX16 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human DHX16 Polyclonal Antibody (HT408014)

개요

이미지

참고 문헌

데이터시트

SDS