Anti-Human ERCC2 Polyclonal Antibody (HB888014)

Name: Anti-Human ERCC2 Polyclonal Antibody
Brand: abinScience
SKU: HB888014
Price: 168 USD
Availability: InStock

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100ug

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개요
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개요

카탈로그 번호

HB888014

설명

Anti-Human ERCC2 Polyclonal Antibody (HB888014) is a rabbit polyclonal antibody detecting ERCC2. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ERCC2 (Cys489-Leu760).

타겟

BTF2 p80, Basic transcription factor 2 80 kDa subunit, CXPD, DNA 5'-3' helicase XPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, EC:5.6.2.3, ERCC2, General transcription and DNA repair factor IIH helicase subunit XPD, TFIIH 80 kDa subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH p80, TFIIH subunit XPD, XPD, XPDC, Xeroderma pigmentosum group D-complementing protein

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

P18074

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) is a ~86 kDa protein. ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognizes damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II.

1. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769

2. Sung, P. et al. (1993) Nature 365, 852-5. PMID: 8413672

3. Coin, F. et al. (1998) Nature genetics 20, 184-8. PMID: 9771713

4. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882

5. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626

6. Mathieu, N. et al. (2013) Current biology : CB 23, 204-12. PMID: 23352696

7. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human ERCC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human ERCC2 Polyclonal Antibody (HB888014)

개요

이미지

참고 문헌

데이터시트

SDS