Anti-Human ERI1 Polyclonal Antibody (HV499014)

Name: Anti-Human ERI1 Polyclonal Antibody
Brand: abinScience
SKU: HV499014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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개요

카탈로그 번호

HV499014

설명

Anti-Human ERI1 Polyclonal Antibody (HV499014) is a rabbit polyclonal antibody detecting ERI1. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human ERI1 (Pro64-Ser329).

타겟

3'-5' exonuclease ERI1, 3'-5' exoribonuclease 1, 3'EXO, EC:3.1.13.1, ERI1, Eri-1 homolog, HEXO, Histone mRNA 3'-end-specific exoribonuclease, Histone mRNA 3'-exonuclease 1, Protein 3'hExo, THEX1

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

Q8IV48

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

3'-5' exoribonuclease 1 (ERI1) is a ~40 kDa protein. RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient 3'-end histone mRNA exonuclease activity and degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Required for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs.

1. Dominski, Z. et al. (2003) Molecular cell 12, 295-305. PMID: 14536070

2. Yang, XC. et al. (2006) The Journal of biological chemistry 281, 30447-54. PMID: 16912046

3. Kupsco, JM. et al. (2006) RNA (New York, N.Y.) 12, 2103-17. PMID: 17135487

4. Guo, L. et al. (2023) American journal of human genetics 110, 1068-1085. PMID: 37352860

5. Kennedy, S. et al. (2004) Nature 427, 645-9. PMID: 14961122

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human ERI1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human ERI1 Polyclonal Antibody (HV499014)

개요

이미지

참고 문헌

데이터시트

SDS