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| 카탈로그 번호 | HB844013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1955 | ||||
| 타겟 | Proteinase-activated receptor 1, PAR-1, PAR1, CF2R, Coagulation factor II receptor, Thrombin receptor, F2R, TR | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P25116 | ||||
| RRID | Anti-Human F2R/PAR1 Antibody (SAA1955) (abinScience Cat# HB844013, RRID:AB_3727719) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | Proteinase-activated receptor 1 (F2R/PAR1) is a ~47 kDa protein. High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores. The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores. In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation. May play a role in platelets activation and in vascular development. Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells. 1. Vu, TK. et al. (1991) Cell 64, 1057-68. PMID: 1672265 2. Mathews, II. et al. (1994) Biochemistry 33, 3266-79. PMID: 8136362 3. Kahn, ML. et al. (1999) The Journal of clinical investigation 103, 879-87. PMID: 10079109 4. Shinozawa, E. et al. (2018) Frontiers in pharmacology 9, 1431. PMID: 30568593 5. D'Alessandro, E. et al. (2021) Cells 10. PMID: 34831181 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human F2R/PAR1 Antibody (SAA1955)
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
