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| 카탈로그 번호 | HY232137 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | ELISA, FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA0436 |
| 접합 | APC |
| 타겟 | Endothelial cell growth factor, HBGF-1, Fibroblast growth factor 1, FGF1, ECGF, Acidic fibroblast growth factor, aFGF, Heparin-binding growth factor 1, FGF-1, FGFA |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173), APC |
| 등록번호 | P05230 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Fibroblast growth factor 1 (FGF1/aFGF) is a ~17 kDa protein. Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. 1. Mori, S. et al. (2008) The Journal of biological chemistry 283, 18066-75. PMID: 18441324 2. Yamaji, S. et al. (2010) PloS one 5, e10273. PMID: 20422052 3. Mori, S. et al. (2013) PloS one 8, e57927. PMID: 23469107 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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