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| 카탈로그 번호 | HW827014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human FXR1 (Met1-Ala173). | ||||||||
| 타겟 | Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P51114 | ||||||||
| RRID | Anti-Human FXR1 Polyclonal Antibody (abinScience Cat# HW827014, RRID:AB_3730721) |
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| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | RNA-binding protein FXR1 is a ~69 kDa protein. mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids. Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site. 1. Vasudevan, S. et al. (2007) Cell 128, 1105-18. PMID: 17382880 2. Say, E. et al. (2010) Molecular cell 38, 236-49. PMID: 20417602 3. Herman, AB. et al. (2018) Cell reports 24, 1176-1189. PMID: 30067974 4. George, J. et al. (2021) Cell reports 37, 109934. PMID: 34731628 5. Ling, H. et al. (2022) Oncogene 41, 4433-4445. PMID: 35989368 6. Datta, C. et al. (2022) Science advances 8, eabo1304. PMID: 36306353 9. Fischer-Kešo, R. et al. (2014) Molecular and cellular biology 34, 4244-56. PMID: 25225333 | ||||||||
| 참고사항 | For research use only. |
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