Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014)

Name: Anti-Human GluN2D/NR2D Polyclonal Antibody
Brand: abinScience
SKU: HT027014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HT027014

설명

Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014) is a rabbit polyclonal antibody detecting GluN2D. Suitable for Mouse, Rat, and Human.

Highlights

●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human GluN2D/NR2D (Arg49-Tyr413).

타겟

EB11, GRIN2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate receptor ionotropic, NMDA 2D, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O15399

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Glutamate receptor ionotropic, NMDA 2D (GluN2D/NR2D) is a ~143 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.

1. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626

2. Li, D. et al. (2016) American journal of human genetics 99, 802-816. PMID: 27616483

3. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851

4. Hess, SD. et al. (1998) Journal of neurochemistry 70, 1269-79. PMID: 9489750

5. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Human GluN2D/NR2D Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human GluN2D/NR2D Polyclonal Antibody (HT027014)

개요

이미지

참고 문헌

데이터시트

SDS