Anti-Human Guanylyl Cyclase C/GUCY2C Recombinant Antibody (SAA0124), FITC (HB626117)

Name: Anti-Human Guanylyl Cyclase C/GUCY2C Recombinant Antibody (SAA0124), FITC
Brand: abinScience
SKU: HB626117
Price: 223 USD
Availability: InStock

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개요
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개요

카탈로그 번호	HB626117
종 반응성	Human
응용 분야	FCM
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	SAA0124
접합	FITC
타겟	STAR, Intestinal guanylate cyclase, GC-C, GUC2C, STA receptor, Heat-stable enterotoxin receptor, Guanylyl cyclase C, hSTAR, GUCY2C
내독소 수준	< 10 EU/mg
순도	>90% as determined by SDS-PAGE.
관련 제품	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10), FITC
등록번호	P25092
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Store at 4°C for 12 months. Protect from light. Do not freeze.
배경	Guanylyl cyclase C (GUCY2C/GCC) is a ~123 kDa protein. Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin. 1. Scott, RO. et al. (2002) The Journal of biological chemistry 277, 22934-41. PMID: 11950846 2. Singh, S. et al. (1991) Biochemical and biophysical research communications 179, 1455-63. PMID: 1718270 3. Fiskerstrand, T. et al. (2012) The New England journal of medicine 366, 1586-95. PMID: 22436048 4. Romi, H. et al. (2012) American journal of human genetics 90, 893-9. PMID: 22521417 5. Arshad, N. et al. (2013) The Journal of biological chemistry 288, 3907-17. PMID: 23269669 6. de Sauvage, FJ. et al. (1991) The Journal of biological chemistry 266, 17912-8. PMID: 1680854 7. Mann, EA. et al. (1993) The American journal of physiology 264, G172-8. PMID: 8381596
참고사항	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

이미지

Flow cytometry

Flow cytometry analysis was performed using anti-human GUCY2C monoclonal antibody. CHO cells transiently transfected with human GUCY2C plasmids were incubated with an irrelevant antibody (blue histogram) or FITC-conjugated anti-human GUCY2C monoclonal antibody (Catalog # HB626117, green histogram) at a concentration of 5 µg/mL for 30 min at room temperature. After washing, cells were directly analyzed on a NovoCyte Flow Cytometer.

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