Anti-Human IL-2 Recombinant Antibody (SAA0370) (HX011107)

Name: Anti-Human IL-2 Recombinant Antibody (SAA0370)
Brand: abinScience
SKU: HX011107
Price: 196 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HX011107
종 반응성	Human
응용 분야	ELISA, FCM
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG2a
클론 ID	SAA0370
타겟	IL2, IL-2, Aldesleukin, Interleukin-2, TCGF, T-cell growth factor
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P60568
형태	Liquid
저장 완충액	0.01M PBS, pH 7.4, 0.09% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
배경	Interleukin-2 (IL2) is a ~17 kDa protein. Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. 1. Mingari, MC. et al. (1984) Nature 312, 641-3. PMID: 6438535 2. Wang, X. et al. (2005) Science (New York, N.Y.) 310, 1159-63. PMID: 16293754 3. Stauber, DJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2788-93. PMID: 16477002 4. Miyazaki, T. et al. (1994) Science (New York, N.Y.) 266, 1045-7. PMID: 7973659 5. Kirken, RA. et al. (1995) Cytokine 7, 689-700. PMID: 8580378 6. Osinalde, N. et al. (2015) Proteomics 15, 520-31. PMID: 25142963 7. Holbrook, NJ. et al. (1984) Proceedings of the National Academy of Sciences of the United States of America 81, 1634-8. PMID: 6608729
참고사항	For research use only.