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| 카탈로그 번호 | HV999107 |
|---|---|
| 종 반응성 | Human |
| 응용 분야 | ELISA, FCM |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | SAA0391 |
| 타겟 | Interleukin-22, Cytokine Zcyto18, IL-22, ZCYTO18, IL22, ILTIF, IL-TIF, IL-10-related T-cell-derived-inducible factor |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q9GZX6 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.09% Sodium azide. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Interleukin-22 (IL22) is a ~20 kDa protein. Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. 1. Brand, S. et al. (2007) American journal of physiology. Gastrointestinal and liver physiology 292, G1019-28. PMID: 17204547 2. Xie, MH. et al. (2000) The Journal of biological chemistry 275, 31335-9. PMID: 10875937 3. Jones, BC. et al. (2008) Structure (London, England : 1993) 16, 1333-44. PMID: 18599299 4. Akil, H. et al. (2015) PloS one 10, e0119872. PMID: 25793261 5. Moniruzzaman, M. et al. (2019) International journal of molecular sciences 20. PMID: 31311100 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human IL22 Antibody (SAA0391)
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