中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HP060014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human INPP5D (Pro298-Gly711). | ||||||||
| 타겟 | Inositol polyphosphate-5-phosphatase D, p150Ship, hp51CN, INPP5D, SH2 domain-containing inositol 5'-phosphatase 1, SHIP, SHIP1, Phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 1, SHIP-1, SIP-145, Phosphatidylinositol 4, 5-bisphosphate 5-phosphatase, SH2 domain-containing inositol phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q92835 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||||||
| 제품 사용 정보 |
| ||||||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) is a ~133 kDa protein. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. 1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 10764818 2. Kavanaugh, WM. et al. (1996) Current biology : CB 6, 438-45. PMID: 8723348 3. Drayer, AL. et al. (1996) Biochemical and biophysical research communications 225, 243-9. PMID: 8769125 4. Odai, H. et al. (1997) Blood 89, 2745-56. PMID: 9108392 5. Vaillancourt, M. et al. (2006) Cellular signalling 18, 2022-32. PMID: 16682172 | ||||||||
| 참고사항 | For research use only. |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
