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| 카탈로그 번호 | HP281014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KAT8 (Glu158-Lys432). | ||||||||
| 타겟 | MYST-1, hMOF, Histone acetyltransferase KAT8, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1, KAT8, MYST1, MOF, Lysine acetyltransferase 8 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9H7Z6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Histone acetyltransferase KAT8 is a ~52 kDa protein. Histone acetyltransferase that catalyzes histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) or 'Lys-16' (H4K16ac), depending on the context. Catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction. H4K16ac constitutes the only acetylation mark intergenerationally transmitted and regulates key biological processes, such as oogenesis, embryonic stem cell pluripotency, hematopoiesis or glucose metabolism. The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac. The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. 1. Pardo, PS. et al. (2002) The Journal of biological chemistry 277, 50860-6. PMID: 12397079 2. Smith, ER. et al. (2005) Molecular and cellular biology 25, 9175-88. PMID: 16227571 3. Mendjan, S. et al. (2006) Molecular cell 21, 811-23. PMID: 16543150 4. Cai, Y. et al. (2010) The Journal of biological chemistry 285, 4268-72. PMID: 20018852 5. Kadlec, J. et al. (2011) Nature structural & molecular biology 18, 142-9. PMID: 21217699 6. Yuan, H. et al. (2012) The EMBO journal 31, 58-70. PMID: 22020126 7. Huang, J. et al. (2012) Cell research 22, 1078-81. PMID: 22547026 8. Li, L. et al. (2020) The Journal of clinical investigation 130, 1431-1445. PMID: 31794431 9. Monserrat, J. et al. (2021) Nature cell biology 23, 401-412. PMID: 33837287 | ||||||||
| 참고사항 | For research use only. |
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