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| 카탈로그 번호 | HD515014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human KLHL24 Polyclonal Antibody (HD515014) is a rabbit polyclonal antibody detecting KLHL24. Suitable for Human, Rat, and Mouse.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human KLHL24 (Arg306-Leu600). | ||||||||
| 타겟 | DRE1, KLHL24, KRIP6, Kainate receptor-interacting protein for GluR6, Kelch-like protein 24, Protein DRE1 | ||||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q6TFL4 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 배경 | Kelch-like protein 24 (KLHL24) is a ~68 kDa protein. Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties. Has a crucial role in cardiac development and function. 1. He, Y. et al. (2016) American journal of human genetics 99, 1395-1404. PMID: 27889062 2. Lin, Z. et al. (2016) Nature genetics 48, 1508-1516. PMID: 27798626 3. Hedberg-Oldfors, C. et al. (2019) Human molecular genetics 28, 1919-1929. PMID: 30715372 | ||||||||
| 참고사항 | For research use only |
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