Human KLHL24 Recombinant Protein (N-His) (HD515012)

Name: Human KLHL24 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD515012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HD515012
Description	Recombinant Human KLHL24 Protein, N-His (HD515012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q6TFL4
Protein length	Arg306-Leu600
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	DRE1, KLHL24, KRIP6, Kainate receptor-interacting protein for GluR6, Kelch-like protein 24, Protein DRE1
Background	Kelch-like protein 24 is a ~68 kDa protein. Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties. Has a crucial role in cardiac development and function. 1. He, Y. et al. (2016) American journal of human genetics 99, 1395-1404. PMID: 27889062 2. Lin, Z. et al. (2016) Nature genetics 48, 1508-1516. PMID: 27798626 3. Hedberg-Oldfors, C. et al. (2019) Human molecular genetics 28, 1919-1929. PMID: 30715372
Note	For research use only

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Datasheet

Human KLHL24 Recombinant Protein (N-His).pdf

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Human KLHL24 Recombinant Protein (N-His) (HD515012)

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