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Anti-Human KLHL24 Polyclonal Antibody (HD515014)

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Overview
Catalog No.HD515014
Description
Anti-Human KLHL24 Polyclonal Antibody (HD515014) is a rabbit polyclonal antibody detecting KLHL24. Suitable for Human, Rat, and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human KLHL24 (Arg306-Leu600).
Target DRE1, KLHL24, KRIP6, Kainate receptor-interacting protein for GluR6, Kelch-like protein 24, Protein DRE1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q6TFL4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Kelch-like protein 24 (KLHL24) is a ~68 kDa protein. Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties. Has a crucial role in cardiac development and function.

1. He, Y. et al. (2016) American journal of human genetics 99, 1395-1404. PMID: 27889062
2. Lin, Z. et al. (2016) Nature genetics 48, 1508-1516. PMID: 27798626
3. Hedberg-Oldfors, C. et al. (2019) Human molecular genetics 28, 1919-1929. PMID: 30715372
Note For research use only
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Datasheet
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Formula
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V₁ (Stock Vol.)
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Anti-Human KLHL24 Polyclonal Antibody

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