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| 카탈로그 번호 | HF904013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1513 | ||||
| 타겟 | c-Ki-ras, RASK2, GTPase KRas, K-Ras 2, c-K-ras, KRAS, Ki-Ras, KRAS2 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P01116 | ||||
| RRID | Anti-Human KRAS/K-Ras 2 Antibody (SAA1513) (abinScience Cat# HF904013, RRID:AB_3727274) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | GTPase KRas (K-Ras 2) is a ~21 kDa protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. 1. Gremer, L. et al. (2011) Human mutation 32, 33-43. PMID: 20949621 2. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765 3. Yang, MH. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10843-8. PMID: 22711838 4. Zimmermann, G. et al. (2013) Nature 497, 638-42. PMID: 23698361 5. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human KRAS/K-Ras 2 Antibody (SAA1513)
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