Anti-KRAS/K-Ras 2 Polyclonal Antibody (HF904024)

Name: Anti-KRAS/K-Ras 2 Polyclonal Antibody
Brand: abinScience
SKU: HF904024
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HF904024

Description

Anti-KRAS/K-Ras 2 Polyclonal Antibody (HF904024) is a rabbit polyclonal antibody detecting K-Ras 2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human KRAS/K-Ras 2 (Gly13-Cys185).

Target

c-Ki-ras, RASK2, GTPase KRas, K-Ras 2, c-K-ras, KRAS, Ki-Ras, KRAS2

Purification

Purified by antigen affinity column.

Accession

P01116

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

GTPase KRas (K-Ras 2) is a ~21 kDa protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.

1. Gremer, L. et al. (2011) Human mutation 32, 33-43. PMID: 20949621

2. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765

3. Yang, MH. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10843-8. PMID: 22711838

4. Zimmermann, G. et al. (2013) Nature 497, 638-42. PMID: 23698361

5. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-KRAS/K-Ras 2 polyclonal antibody at 1ug/mL on recombinant KRAS/K-Ras 2 (Catalog No. HF904052).

References

Datasheet