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| 카탈로그 번호 | HF904023 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human KRAS Nanobody (SBT-100) [SBT-100] (HF904023) is a alpaca monoclonal antibody detecting KRAS in ELISA, IF. Suitable for Human.
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| 종 반응성 | Human | ||||
| 응용 분야 | ELISA, IF | ||||
| 숙주 종 | Alpaca | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-His | ||||
| 클론 ID | SBT-100 | ||||
| 타겟 | EC:3.6.5.2, GTPase KRas, GTPase KRas, N-terminally processed, K-Ras 2, KRAS, KRAS2, Ki-Ras, RASK2, c-K-ras, c-Ki-ras | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by Nickel column. | ||||
| 등록번호 | P01116 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | GTPase KRas is a ~21 kDa protein. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Activates MAPK1/MAPK3 resulting in phosphorylation and ultimately degradation of GJA1. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. 1. Gremer, L. et al. (2011) Human mutation 32, 33-43. PMID: 20949621 2. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765 3. Yang, MH. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10843-8. PMID: 22711838 4. Zimmermann, G. et al. (2013) Nature 497, 638-42. PMID: 23698361 5. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306 | ||||
| 참고사항 | For research use only |
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