Anti-Human LBR Polyclonal Antibody (HC667014)

Name: Anti-Human LBR Polyclonal Antibody
Brand: abinScience
SKU: HC667014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HC667014

설명

Anti-Human LBR Polyclonal Antibody (HC667014) is a rabbit polyclonal antibody detecting LBR in ELISA, IHC, WB. Suitable for Human, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human LBR (Ala7-Arg61).

타겟

LMN2R, LBR, C14SR, Integral nuclear envelope inner membrane protein, Sterol C14-reductase, 3-beta-hydroxysterol Delta (14)-reductase, Delta(14)-sterol reductase LBR, Lamin-B receptor, Delta-14-SR, C-14 sterol reductase

정제

Purified by antigen affinity column.

등록번호

Q14739

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Delta(14)-sterol reductase LBR is a ~70 kDa protein. Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane.

1. Waterham, HR. et al. (2003) American journal of human genetics 72, 1013-7. PMID: 12618959

2. Bennati, AM. et al. (2006) Biochimica et biophysica acta 1761, 677-85. PMID: 16784888

3. Clayton, P. et al. (2010) Nucleus (Austin, Tex.) 1, 354-66. PMID: 21327084

4. Tsai, PL. et al. (2016) eLife 5. PMID: 27336722

5. Silve, S. et al. (1998) Biochimica et biophysica acta 1392, 233-44. PMID: 9630650

6. Duband-Goulet, I. et al. (2000) Biochemistry 39, 6483-8. PMID: 10828963

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human LBR Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human LBR Polyclonal Antibody (HC667014)

개요

이미지

참고 문헌

데이터시트

SDS