中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HV980023 | ||||
|---|---|---|---|---|---|
| 설명 |
Anti-Human LGR4 Nanobody (SAA2295) [SAA2295] (HV980023) is a alpaca monoclonal antibody detecting LGR4 in ELISA. Suitable for Human.
|
||||
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Alpaca | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | VHH-His | ||||
| 클론 ID | SAA2295 | ||||
| 타겟 | G-protein coupled receptor 48, GPR48, LGR4, Leucine-rich repeat-containing G-protein coupled receptor 4 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Purified by Nickel column. | ||||
| 등록번호 | Q9BXB1 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
||||
| 제품 사용 정보 |
| ||||
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4) is a ~104 kDa protein. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. | ||||
| 참고사항 | For research use only |
SDS-PAGE for Anti-Human LGR4 Nanobody (SAA2295)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
