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| 카탈로그 번호 | HP792014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Human LGR6 Polyclonal Antibody (HP792014) is a rabbit polyclonal antibody detecting LGR6 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human LGR6 (Ala37-Gly483). | ||||||||
| 타겟 | Leucine-rich repeat-containing G-protein coupled receptor 6, LGR6 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q9HBX8 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6) is a ~104 kDa protein. Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. | ||||||||
| 참고사항 | For research use only. |
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