Anti-Human MBL-2 Polyclonal Antibody (HY274014)

Name: Anti-Human MBL-2 Polyclonal Antibody
Brand: abinScience
SKU: HY274014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

HY274014

설명

Anti-Human MBL-2 Polyclonal Antibody (HY274014) is a rabbit polyclonal antibody detecting MBL-2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human MBL2/MBP-C (Gly131-Ile248).

타겟

COLEC1, Mannose-binding protein C, MBL2, Mannan-binding protein, MBP1, Mannose-binding lectin, MBL, Collectin-1, MBP-C

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

P11226

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Mannose-binding protein C (MBL2/MBP-C) is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA.

1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269

2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085

3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089

4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411

5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758

6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429

7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295

8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Human MBL-2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human MBL-2 Polyclonal Antibody (HY274014)

개요

이미지

참고 문헌

데이터시트

SDS