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| 카탈로그 번호 | HW687013 | ||||
|---|---|---|---|---|---|
| 종 반응성 | Human | ||||
| 응용 분야 | ELISA | ||||
| 숙주 종 | Mouse | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG2a, kappa | ||||
| 클론 ID | SAA1630 | ||||
| 타겟 | DNA replication licensing factor MCM7, MCM2, P1.1-MCM3, CDC47 homolog, MCM7, CDC47 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P33993 | ||||
| RRID | Anti-Human MCM7 Antibody (SAA1630) (abinScience Cat# HW687013, RRID:AB_3727391) |
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| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 배경 | DNA replication licensing factor MCM7 is a ~81 kDa protein. Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage. 1. Ishimi, Y. et al. (2015) Journal of biochemistry 157, 561-9. PMID: 25661590 2. Rzechorzek, NJ. et al. (2020) Nucleic acids research 48, 6980-6995. PMID: 32453425 3. Jones, ML. et al. (2021) The EMBO journal 40, e108819. PMID: 34694004 4. Jenkyn-Bedford, M. et al. (2021) Nature 600, 743-747. PMID: 34700328 5. Baris, Y. et al. (2022) Nature 606, 204-210. PMID: 35585232 6. Ishimi, Y. (1997) The Journal of biological chemistry 272, 24508-13. PMID: 9305914 | ||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Human MCM7 Antibody (SAA1630)
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