Anti-Human MEFV Polyclonal Antibody (HB572014)

Name: Anti-Human MEFV Polyclonal Antibody
Brand: abinScience
SKU: HB572014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

HB572014

설명

Anti-Human MEFV Polyclonal Antibody (HB572014) is a rabbit polyclonal antibody detecting Pyrin; Marenostrin; MEFV; MEF; TRIM20 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant human MEFV (Glu589-Asp781).

타겟

Pyrin; Marenostrin; MEFV; MEF; TRIM20

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O15553

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Pyrin (MEFV) is a ~86 kDa protein. Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production. Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection.

1. Centola, M. et al. (2000) Blood 95, 3223-31. PMID: 10807793

2. Mansfield, E. et al. (2001) Blood 98, 851-9. PMID: 11468188

3. Yu, JW. et al. (2006) Cell death and differentiation 13, 236-49. PMID: 16037825

4. Chae, JJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 9982-7. PMID: 16785446

5. Papin, S. et al. (2007) Cell death and differentiation 14, 1457-66. PMID: 17431422

6. Yu, JW. et al. (2007) Molecular cell 28, 214-27. PMID: 17964261

7. Chae, JJ. et al. (2008) Blood 112, 1794-803. PMID: 18577712

8. Waite, AL. et al. (2009) Experimental biology and medicine (Maywood, N.J.) 234, 40-52. PMID: 19109554

9. Waite, AL. et al. (2009) PloS one 4, e6147. PMID: 19584923

10. Kimura, T. et al. (2015) The Journal of cell biology 210, 973-89. PMID: 26347139

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Human MEFV Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human MEFV Polyclonal Antibody (HB572014)

개요

이미지

참고 문헌

데이터시트

SDS